ORIGINAL ARTICLE
Structure-activity relationship study for fungicidal activity of 1-(4-phenoxymethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1H-1,2,4-triazole derivatives against rice blast
1
Department of Biotechnology, Faculty of Bioresource Sciences, Akita Prefectural University, 241-438, Shimoshinjo Nakano,
Akita 010-0195, Japan
Submission date: 2015-03-18
Acceptance date: 2015-10-23
Corresponding author
Keimei Oh
Department of Biotechnology, Faculty of Bioresource Sciences, Akita Prefectural University, 241-438, Shimoshinjo Nakano, Akita 010-0195, Japan
Department of Biotechnology, Faculty of Bioresource Sciences, Akita Prefectural University, 241-438, Shimoshinjo Nakano, Akita 010-0195, Japan
Journal of Plant Protection Research 2015;55(4):383-388
KEYWORDS
brassinsoteroid biosynthesis inhibitorsfungicideMagnaporthe oryzaerice blast diseasetriazole derivatives
TOPICS
ABSTRACT
To explore new antifungal agents for rice blast control, the antifungal activity of a series of novel 1,2,4-triazole derivatives
against
Magnaporthe oryzae
has been evaluated. The antifungal activity was determined by using
in vitro
mycelial growth inhibition
tests. Among the 19 test compounds, we found that the compound 1-(4-phenoxymethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1
H
-1,2,4-
triazole (Gj
) displayed potent antifungal activity against
M. oryzae. The IC
50
value was found approximately 3.8±0.5 μM and the IC
50
value of propiconazole was found to be approximately 3.7±0.2 μM, respectively. Structure-activity relationship studies on aromatic
ring structures provided insight and information about the structural requirements for antifungal activity of this synthetic series
against
M. oryzae
CONFLICT OF INTEREST
The authors have declared that no conflict of interests exist.
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| ISSN: | 1427-4345 |
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