In contrast to other plant pathogens, the control of viruses through chemical compounds is not feasible Consequently, the management of plant viruses has predominantly relied on biotechnological approaches rather than those used for other pathogens. This paper presents a thorough review that takes into account an extensive literature analysis to offer a comprehensive understanding of biotechnological strategies aimed at developing stable engineered virus-resistant plants. This paper gives a comprehensive review of literature dealing with biotechnological-based strategies for producing stable engineered virus-resistant plants. Examples of these strategies were highlighted in crops, using as many cases as were available, where these strategies had been used, including cross-protection, pathogen-derived resistance (PDR), hairpin RNA, artificial small RNAs, and genome editing-based CRISPR/Cas systems. In evaluating the trends over time, we have critically assessed the advantages and disadvantages of each approach, identifying synthetic trans-acting microRNA (syn-tasiRNA) and CRISPR/Cas as the most effective and precise methods exhibiting minimal off-target effects on the plant genome. Furthermore, we have discussed the emerging innovations in non-transgenic resistance strategies such as the application of double-stranded (ds) RNA which hold promise for overcoming the significant challenges associated with the commercialization of engineered resistant plants.