The experiment was conducted in the years 2001–2003 at the Experimental Station in Złotniki. The aim of the performed investigations was to evaluate economic effectiveness of different fungicidal protection programs in winter wheat. Winter wheat of cv. Sakwa was cultivated using the following two variants of seed treatment: 1) Raxil 060 FS at the dose of 60 ml/100 kg grain, 2) Raxil 060 FS + Latitude 125 FS at the doses of 60 and 200 ml/100 kg, and five variants of fungicidal foliar protection: 1) Vista 228 SE, 2) Sportak Alpha 380 EC, 3) Sportak Alpha 380 EC + Vista 228 SE, 4) Sportak Alpha 380 EC + Vista 228 SE + Juwel 250 SC, 5) control – without protection. The use of the above plant protection products contributed to the increase of winter wheat grain yield from 0.60 t/ha to 2.07 t/ha. This increase of yield covered costs of performed chemical control. The economic analysis showed that most effective variant of winter wheat chemical protection was seed treatment with Latitude 125 FS with additional two foliar treatments with the following fungicides: Sportak Alpha 380 EC and Vista 228 SE. Irrespective of the applied seed dressing, additional application of Juwel 250 SC at the stage of early milk maturity turned out to be economically not justified.